This advanced clinical reference provides a comprehensive comparison of anxiolytics and sleep aids, including benzodiazepines, non-benzodiazepine hypnotics, melatonin receptor agonists, antihistamines, and novel agents. It highlights each medication’s mechanism of action, half-life, onset and duration, dosing guidelines, and metabolism pathways. Clinical uses are outlined for conditions such as generalized anxiety disorder, panic disorder, acute agitation, insomnia, and circadian rhythm disturbances.

The guide also reviews safety considerations such as tolerance, dependence, withdrawal, and next-day impairment. Special population guidance is provided for elderly patients, adolescents, and pregnancy. Augmentation and combination strategies are included for treatment-resistant anxiety or chronic insomnia. Side effect profiles are compared with tips for management and monitoring. Designed as a practical and visual tool, this reference supports evidence-based prescribing and enhances clinical decision-making for healthcare providers.