Non-stimulant medications offer a valuable alternative for individuals with ADHD who may not tolerate or respond well to traditional stimulants. Acting as the brain’s “gentle focus team,” these meds—like atomoxetine, guanfacine, and clonidine—provide smoother, longer-lasting attention support without the risk of abuse or pronounced side effects like insomnia or appetite suppression. They’re especially helpful in patients with comorbid anxiety, tics, or a history of substance use.
This section supports psychiatric NPs in understanding when to consider non-stimulants, how to initiate and titrate them, and what to monitor throughout treatment. You’ll get insights into their mechanisms (norepinephrine reuptake inhibition or alpha-2 agonism), expected onset times, and tips for maximizing adherence. For many patients, these medications offer a more balanced path to focus and calm.