Monoamine oxidase inhibitors (MAOIs) are powerful antidepressants that operate like elite special forces—reserved for treatment-resistant cases where other medications have failed. By inhibiting the MAO enzyme, they prevent the breakdown of neurotransmitters like serotonin, dopamine, and norepinephrine, leading to increased mood-enhancing activity in the brain. However, their potency comes with strict dietary restrictions and serious drug interaction risks, including hypertensive crises.
This section helps psychiatric NPs navigate the precise use of MAOIs like phenelzine, tranylcypromine, and selegiline. You’ll learn key safety protocols, necessary washout periods when switching medications, and how to counsel patients on avoiding tyramine-rich foods and contraindicated drugs. Used with caution and expertise, MAOIs can be life-changing for those who need them most.